Cyclophosphamide

CYCLOPHOSPHAMIDE – ORAL, INJECTION (sye-klo-FOSS-fuh-mide)

COMMON BRAND NAME(S): Cytoxan, Neosar

USES: Cyclophosphamide is used to treat different types of cancer.

OTHER USES: This medication may also be used to treat a variety of rheumatoid diseases including rheumatoid arthritis and lupus, and has other uses as determined by your doctor.

HOW TO TAKE THIS MEDICATION: This is a powerful medication. Use it exactly as prescribed. While you are using this medication, you must drink more fluid than usual and pass urine frequently. This helps your kidneys to remove the drug from your body and avoid some of the side effects. Ask your doctor how much you should drink and how often to empty your bladder each day and follow these instructions carefully. Do not stop using this medication, even if you feel nauseated or experience vomiting. If you vomit shortly after a dose, or if you miss a dose, contact your doctor.

SIDE EFFECTS: Nausea, vomiting, loss of appetite, diarrhea, rash, hives, itch, stomach pain, darkening of skin/nails, headache, flushing or red face, sweating, or swollen lips are common side effects. Using the medication on an empty stomach with a full glass of water may help relieve vomiting. Changes in diet such as eating several small meals or limited activity may help lessen some of these effects. Temporary hair loss is another common side effect; normal hair growth should return after treatment has ended. Notify your doctor immediately if you develop: pink or bloddy uring. An allergic reaction to this drug is unlikely, but seek immediate medical attention if it occurs. Symptoms of an allergic reaction include: rash, itching, swelling, dizziness, trouble breathing. If you notice other effects not listed above, contact your doctor or pharmacist.

PRECAUTIONS: Tell your doctor your medical history, especially of:

DRUG INTERACTIONS: Tell your doctor of all over-the-counter or prescription medication you may use, including:

OVERDOSE: If overdose is suspected, contact your local poison control center or emergency room immediately. Symptoms of overdose may include red or bloody urine, back or stomach pain, weakness, and fast heartbeat.

NOTES: Regular doctor visits are important. Frequent blood and urine tests will be done to monitor therapy and prevent side effects.

MISSED DOSE: For optimal benefits, it is important to receive each scheduled dose of this medication as directed. If you miss a dose, inform your doctor. Do not ‘double-up’ the dose to catch up.

STORAGE: Store tablets between 36 and 77 degrees F (between 2.2 and 25 degrees C) away from moisture and sunlight. Store the powder for injection below 77 degrees F (below 25 degrees C). Refrigerate but do not freeze the oral solution.