Sodium Fluoride

Otospongiosis Therapy

Otospongiosis Therapy

Indications And Clinical Uses: Nonsurgical cases: In patients with diagnosed neurosensorial hearing loss or tinnitus due to otospongiosis, especially if accompanied by a positive Schwartze sign indicating a vascular active focus.

Postsurgical cases: In patients where, following surgery, a soft vascular focus is encountered at the oval window or when the patient begins to experience progressive neurosensorial deterioration after successful stapedectomy.

Adverse Reactions: Sodium fluoride, at the recommended dosage, is usually well tolerated. Mild reactions consisting of gastrointestinal complaints, musculoskeletal pain and skin rash may occur.

Symptoms And Treatment Of Overdose: Symptoms: Initial symptoms are secondary to the local action of sodium fluoride on the mucosa of the gastrointestinal tract. Salivation, nausea, abdominal pain, vomiting, and diarrhea are frequent. Systemic symptoms are varied and severe. The patient shows signs of increasing irritability of the nervous system, including paresthesias, a positive Chvostek sign, hyperactive reflexes, and tonic and clonic convulsions.

Treatment: 1) Act quickly; 2) Start i.v. therapy with glucose in isotonic saline solution to maintain blood sugar and to have a venous channel available for transfusion in the event of shock; 3) Wash the stomach with limewater (0.15% calcium hydroxide solution) and then give limewater at frequent intervals; 4) Have calcium gluconate available for i.v. administration and watch closely for signs of tetany; 5) Maintain high urine volumes with parenteral fluid.

Dosage And Administration: The average dose of Fluotic is 20 mg 3 times a day with meals. Clinical experience with sodium fluoride in osteoporosis, multiple myeloma and otospongiosis has shown that best results can be achieved by the addition of a calcium salt and of vitamin D.

Control of patients: It is important to make periodic examinations of patients as follows:

Availability And Storage: Each red, enteric film-coated tablet contains: sodium fluoride 20 mg. Nonmedicinal ingredients: cellulose acetate phthalate, colloidal silicon dioxide, diethyl phthalate, FD&C red #40 aluminum lake, FD&C yellow #6 aluminum lake, hydroxypropyl methylcellulose, lactose, microcrystalline cellulose, polyethylene glycol, polysorbate, stearic acid and titanium dioxide. Gluten-free. Bottles of 100