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Depakote is a valproic acid derivative. It is classified as an anticonvulsant drug. The generic name of this drug is Divalproex.

Mechanism of Action:

The active ingredient of this drug which is Divalproex, is believed to bind and inhibit gamma aminobutyric acid (GABA). Its anticonvulsant activity may be related to the increased brain concentrations of GABA (it is an inhibitory neurotransmitter in the CNS). This results to the inhibition of the enzymes that catabolize GABA or prevents the reuptake of GABA into glia and nerve endings. It may also work by suppressing the repetitive neuronal firing through the blockage of voltage-sensitive sodium channels.

Indications:

This medication is advisable to be used in patients who have simple and complex absence seizures, mixed seizure types, complex partial seizures, mania, and migraine headache.

Contraindications:

Depakote is not advisable to be used in patients who have hypersensitivity to the drug or to its components. It is also not advisable to be used in patients who are pregnant, lactating, and children. It is not given in patients who are suffering from hepatic impairment or dysfunction and UCD (urea cycle disorder).

Side Effects:

Dizziness, nausea, vomiting, tiredness, tremors, stomach upset, hair loss, and weight gain

Adverse Effects:

Low-grade fever, chest pain, difficulty in breathing, dark-colored urine, clay-colored stools, and jaundice

Important Reminders:

Instruct the patient to take this medication as prescribed by the doctor. Instruct the patient not to chew, crush, or break it when he takes the medication. This should not be taken in larger amounts, or taken for longer periods recommended by the doctor. Advise him not to withdraw from using Depakote abruptly. Explain the importance of having a regular check up and complying with the required laboratory tests to the patient. Encourage the patient to increase oral fluid intake while he is taking this medication.

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