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Azulfidine drug description and what Azulfidine is used to treat

Azulfidine is a pro-drug that is not active in its ingested form. It is used to treat ulcerative colitis. The inflammation of ulcerative colitis and other inflammatory diseases is caused by excessive production of chemicals (prostaglandins) that produce inflammation. Prostaglandins are produced by two enzymes: cyclooxygenase and lipoxygenase.

Azulfidine is broken down by bacteria in the colon into 5-aminosalicylic acid (5-ASA), and sulfapyridine. The 5-ASA is also known as mesalamine (Lialda, Rowasa, Pentasa, Canasa Apriso, and Asacol.) The 5-ASA has therapeutic benefit, but it is not clear if sulfapyridine adds any additional therapeutic benefit. These enzymes are over-active in individuals with ulcerative colitis. 5-ASA may reduce inflammation by blocking the activity of cyclooxygenase and lipoxygenase thereby reducing the production of prostaglandins. It is used to treat mild to moderately severe ulcerative colitis. Ulcerative colitis is the inflammation of the walls of the bowel accompanied by the formation of ulcers.

Azulfidine does not cure ulcerative colitis, it only decreases symptoms brought by it i.e. stomach pain, diarrhea and rectal bleeding due to swelling of the rectum. This medicine is usually given 2 to 4 times per day, depending on the disease for which it is used. It is best to take the medication with foods, so as to prevent stomach upset. It has to be swallowed with water, and not chewed. It is very important to take this medication exactly as prescribed by your physician. If you miss a dose, take it as soon as you remember, and continue with your regular dose. However, it is not advisable to have a double dose of the pill after you missed the previous one. See your doctor immediately if cases as such arise.

All medicines may cause side effects. Although, Azulfidine helps people with ulcerative colitis, it may also have unwanted side effects. Some symptoms of an allergic reaction are rashes, itching or swelling in the face, throat or tongue; severe dizziness and trouble breathing. Most common side effects of this medicine that must not be ignored are headache, nausea, vomiting, or loss of appetite. It is recommended to call your medical care provider if you experience diarrhea. The doctor might lessen the dosage or change it to cure the cause of diarrhea.

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