INDINAVIR DESCRIPTION

Indinavir (Crixivan) - Capsule

Crixivan is manufactured by Merck Frosst Ltd. This medicine is an HIV protease inhibitor used in combination with other medicines to manage human immunodeficiency virus (HIV).

Why is Indinavir prescribed?

Indinavir is used in the treatment of human immunodeficiency virus (HIV) infection. HIV causes the immune system to break down so that it can no longer fight off other infections. This leads to the fatal disease known as acquired immune deficiency syndrome (AIDS). HIV thrives by taking over the immune system's vital CD4 cells (white blood cells) and using their inner workings to make additional copies of itself. Indinavir belongs to a class of HIV drugs called protease inhibitors, which work by interfering with an important step in the virus's reproductive cycle. Although Indinavir cannot eliminate HIV already present in the body, it can reduce the amount of virus available to infect other cells.

Indinavir can be taken alone or in combination with other HIV drugs such as Retrovir. Because Indinavir and Retrovir attack the virus in different ways, the combination is likely to be more effective than either drug alone.

Where can I order Indinavir From? Can I buy Indinavir at Canadian Prices?

Yes, if you are from the U.S. then you can buy Indinavir at Canadian prices. Currently we will only accept an order for Indinavir from U.S. and Canadian residents. Both U.S. and Canadian residents require a prescription to purchase Indinavir and when you order Indinavir it will be delivered with express shipping.

Most important fact

It is important that you drink at least six 8-ounce glasses of liquid (preferably water) daily while taking Indinavir. If you do not get enough liquid, you may develop kidney stones and have to temporarily stop taking Indinavir or even discontinue it altogether.

How should you take Indinavir?

Take exactly as prescribed by your doctor. Do not share this medication with anyone and do not take more than your recommended dosage. To ensure maximum absorption, do not take Indinavir with food. Instead, take it with water 1 hour before or 2 hours after a meal. (Indinavir may also be taken with liquids such as skim milk, juice, coffee, or tea, or even with a light meal such as dry toast with jelly, juice, and coffee with skim milk and sugar, or corn flakes with skim milk and sugar.) --If you miss a dose...Skip it and take the next dose at the regularly scheduled time. Do not double the dose. --Storage instructions...

Indinavir capsules are sensitive to moisture. Store Indinavir at room temperature in the original container and leave the drying agent in the bottle to keep the medication dry. Keep the container tightly closed.

What side effects may occur?

Side effects cannot be anticipated. If any develop or change in intensity, inform your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking Indinavir.

Possible side effects may include:
Abdominal distention and pain, allergic reactions, anemia, back pain, bladder infections, blood in the urine, changes in taste, chest pain and heart disorders, depression, diabetes, diarrhea, discolored skin, dizziness, drowsiness, dry skin and mouth, fatigue, general feeling of illness, hair loss, headache, hives, indigestion, inflamed blood vessels, ingrown toenails, insomnia, itching, joint pain, kidney problems, liver problems, loss of appetite, nausea, numbness of the mouth, pain in the side, rash, redistribution of body fat, skin discoloration, stroke, vomiting, weakness, yellow skin or eyes

Possible food and drug interactions

Do not take with rifampin (Rifadin); it reduces Indinavir's effectiveness. Also avoid the following medications while taking Indinavir. The combination may cause serious or life-threatening effects.

Ergot-based drugs such as Cafergot
Lovastatin (Mevacor)
Midazolam (Versed)
Pimozide (Orap)
Simvastatin (Zocor)
Triazolam (Halcion) It's also best to avoid combining Indinavir with St. John's Wort, which reduces Indinavir's effect. Indinavir may interact with certain other drugs, and the effects of either could be increased, decreased, or altered. It is especially important to check with your doctor before combining Indinavir with the following:

Atorvastatin (Lipitor)
Carbamazepine (Tegretol)
Cerivastatin (Baycol)
Clarithromycin (Biaxin)
Delavirdine (Rescriptor)
Dexamethasone (Decadron)
Didanosine (Videx)
Efavirenz (Sustiva)
Fluconazole (Diflucan)
Fluvastatin (Lescol)
Heart medications known as calcium channel blockers, including Cardizem, Plendil, and Procardia
Isoniazid (Nydrazid)
Itraconazole (Sporanox)
Ketoconazole (Nizoral)
Ortho-Novum
Phenobarbital
Phenytoin (Dilantin)
Pravastatin (Pravachol)
Quinidine (Quinidex)
Rifabutin (Mycobutin)
Rifampin (Rifadin)
Trimethoprim (Bactrim, Trimpex, Septra) Check with your doctor before using Viagra while on Indinavir. Combining the two increases the risk of side effects from Viagra, including low blood pressure, vision problems, and a dangerously prolonged erection. If an erection lasts more than 4 hours, seek medical help immediately to avoid permanent damage to the penis. Avoid drinking grapefruit juice while taking Indinavir. This kind of juice can reduce the drug's effectiveness.

Be sure to tell your doctor and pharmacist about all medications you are taking, both prescription and over-the-counter. Alert them, too, when you stop taking a medication.

Special information if you are pregnant or breastfeeding

The effects during pregnancy have not been adequately studied. If you are pregnant or plan to become pregnant, tell your doctor immediately. Do not breastfeed your baby. HIV appears in breast milk and can infect a nursing infant.

Recommended dosage

ADULTS

The recommended dose is 800 milligrams (usually two 400-milligram capsules) every 8 hours. Your doctor may lower the dose to 600 milligrams every 8 hours if you have mild-to-moderate liver problems due to cirrhosis. The dose will also need adjustment if you are taking Rescriptor, Mycobutin, Nizoral, Sporanox, Sustiva, or Videx.

CHILDREN

Indinavir is more likely to cause kidney stones in children than in adults. If the doctor finds it necessary to prescribe Indinavir anyway, dosage is calculated according to the size of the child.

Overdosage

Any medication taken in excess can have serious consequences. If you suspect an overdose, seek emergency medical treatment immediately.

Symptoms of Indinavir overdose may include:
Back pain, blood in urine, diarrhea, kidney stones, nausea, vomiting

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