ACCOLATE DESCRIPTION
Accolate
Accolate is manufactured by AstraZeneca Pharmaceuticals. This prescription medicine is a leukotriene receptor antagonist used for the prevention and long term treatment of asthma.
ACCOLATE is a nonsteroidal tablet for the prevention and continuous treatment of asthma in adults and children 5 years of age and older, available only by prescription. ACCOLATE IS NOT FOR USE IN THE REVERSAL OF ACUTE ASTHMA ATTACKS.
Much like a rocket has two stages, to reach its destination, ACCOLATE (zafirkulast) has twice-daily dosing, providing 24-hour leukotriene receptor antagonist (LTRA) coverage to help prevent asthma breakthrough. Leukotrienes are natural substances in everyone's body, but in people with asthma, these substances can cause many of the symptoms of asthma.
With its twice-daily dosing, ACCOLATE has been proven to significantly reduce both daytime symptoms and nighttime awakenings due to asthma1,2,3,*.
And, in large-scale clinical trials of nearly 1400 adolescent and adult patients, ACCOLATE significantly reduced rescue-inhaler use (B2-agonist, puffs/day)1,2,3,*. Frequent rescue-inhaler use is an indicator of asthma breakthrough.
Finally, ACCOLATE has been shown to improve airway function, as demonstrated by improvements in traditional measures such as FEV1 and PEFR (peak expiratory flow rate)1,2,3.
*Adolescent and adult patients with mild-to-moderate asthma previously using PRN B2-agonist alone.
ACCOLATE is generally well tolerated. Common side effects for ACCOLATE included headache (12.9%), infection (3.5%),** and nausea (3.1%) in adults and headache (4.5%) and abdominal pain (2.8%) in children. These were not significantly different from placebo.
**In clinical trials, an increased proportion of patients taking ACCOLATE over the age of 55 years reported infections as compared to placebo-treated patients. Infections were generally mild to moderate and predominantly of the respiratory tract.
Where can I order Accolate from? Can I buy Accolate at Canadian prices?
Yes, if you are from the U.S. then you can buy Accolate at Canadian prices. Currently we will only accept an order for Accolate from U.S. and Canadian residents. Both U.S. and Canadian residents require a prescription to purchase Accolate and when you order Accolate it will be shipped with express shipping.
Why is Accolate prescribed?
Accolate helps prevent asthma attacks. It is prescribed for long-term treatment.
Most important fact about Accolate
Accolate will not stop an asthma attack once it starts. You will still need to use an airway-opening medication when an attack occurs.
How should you take Accolate?
Accolate should be taken twice every day, whether or not you have had any recent asthma attacks. Do not take the medication with food. Allow at least 1 hour to pass before eating, or wait for 2 hours after a meal. You can continue to take Accolate while using another medication to stop an attack. --If you miss a dose...Take it as soon as you remember. If it is almost time for your next dose, skip the one you missed and go back to your regular schedule. Do not take 2 doses at once. --Storage instructions...
Store Accolate at room temperature in a dark, dry place.
What Accolate side effects may occur?
Accolate Side effects cannot be anticipated. If any develop or change in intensity, inform your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking Accolate.
More common Accolate side effects may include:
Headache, infection, nausea
Less common Accolate side effects may include:
Accidental injury, abdominal pain, allergic reactions (hives; swelling of the lips, tongue, face, arms, and legs; rash), back pain, diarrhea, dizziness, fever, generalized pain, indigestion, joint pain, muscle aches, vomiting, weakness
Why should Accolate not be prescribed?
If you have had an allergic reaction to Accolate or to any of its ingredients, avoid this drug.
Special warnings about Accolate
While taking Accolate, you should not stop—or even cut down on—any other asthma medication you are using unless your doctor recommends it. Remember that Accolate is not an airway-opening medication. You will still need an inhaler to stop an attack. If you have been taking an oral steroid drug and your doctor does decide to cut back the dosage, there is a remote chance that complications will follow. Inform your doctor of any new symptoms.
Also call your doctor if you develop any of the following: pain in the upper right abdomen, nausea, fatigue, lethargy, loss of appetite, itching, flu-like symptoms, or jaundice (yellowing of the skin and eyes). These are signs of a liver problem—a rare side effect of Accolate that tends to develop more often in women. If tests show the problem to be serious, you'll have to stop using the drug. The symptoms will disappear once you stop.
Possible food and drug interactions when taking Accolate
A full stomach can reduce Accolate's effectiveness. Do not take with meals.
If Accolate is taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your doctor before combining Accolate with the following:
Aspirin (Ecotrin, Genuine Bayer, others)
Astemizole (Hismanal)
Blood-thinning drugs such as Coumadin
Carbamazepine (Tegretol)
Cyclosporine (Sandimmune, Neoral)
Erythromycin (E.E.S., E-Mycin, others)
Heart and blood pressure medications called calcium channel blockers, including Calan, Cardizem, and Procardia
Phenytoin (Dilantin)
Terfenadine (Seldane)
Theophylline (Theo-Dur, others)
Tolbutamide (Orinase)
Special Accolate information if you are pregnant or breastfeeding
Accolate should be taken during pregnancy only if clearly needed. If you are pregnant or plan to become pregnant, inform your doctor immediately.
Accolate does find its way into breast milk and should not be taken by nursing mothers.
Accolate
ACCOLATE is a nonsteroidal tablet for the prevention and continuous treatment of asthma in adults and children 5 years of age and older, available only by prescription. ACCOLATE IS NOT FOR USE IN THE REVERSAL OF ACUTE ASTHMA ATTACKS.
Much like a rocket has two stages, to reach its destination, ACCOLATE (zafirkulast) has twice-daily dosing, providing 24-hour leukotriene receptor antagonist (LTRA) coverage to help prevent asthma breakthrough. Leukotrienes are natural substances in everyone's body, but in people with asthma, these substances can cause many of the symptoms of asthma.
With its twice-daily dosing, ACCOLATE has been proven to significantly reduce both daytime symptoms and nighttime awakenings due to asthma1,2,3,*.
And, in large-scale clinical trials of nearly 1400 adolescent and adult patients, ACCOLATE significantly reduced rescue-inhaler use (B2-agonist, puffs/day)1,2,3,*. Frequent rescue-inhaler use is an indicator of asthma breakthrough.
Finally, ACCOLATE has been shown to improve airway function, as demonstrated by improvements in traditional measures such as FEV1 and PEFR (peak expiratory flow rate)1,2,3.
*Adolescent and adult patients with mild-to-moderate asthma previously using PRN B2-agonist alone.
ACCOLATE is generally well tolerated. Common side effects for ACCOLATE included headache (12.9%), infection (3.5%),** and nausea (3.1%) in adults and headache (4.5%) and abdominal pain (2.8%) in children. These were not significantly different from placebo.
**In clinical trials, an increased proportion of patients taking ACCOLATE over the age of 55 years reported infections as compared to placebo-treated patients. Infections were generally mild to moderate and predominantly of the respiratory tract.
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