ACTONEL DESCRIPTION

Actonel

Actonel is manufactured by Procter & Gamble Pharmaceuticals Inc. and Aventis Pharmaceuticals. ACTONEL (risedronate sodium tablets) is a pyridinyl bisphosphonate that inhibits osteoclast-mediated bone resorption and modulates bone metabolism. This medicine is a bisphosphonate used to prevent and treat osteoporosis that occurs after menopause. It may also be used to treat Paget's disease, steroid-induced osteoporosis, and other conditions as determined by your doctor.

Each ACTONEL tablet for oral administration contains the equivalent of 5 or 30 mg of anhydrous risedronate sodium in the form of the hemi-pentahydrate with small amounts of monohydrate. The empirical formula for risedronate sodium hemi-pentahydrate is C7H10NO7P2Na 2.5 H2O. The chemical name of risedronate sodium is [1-hydroxy-2-(3-pyridinyl)ethylidene]bis[phosphonic acid] monosodium salt.

Risedronate sodium is a fine, white to off-white, odorless, crystalline powder. It is soluble in water and in aqueous solutions, and essentially insoluble in common organic solvents.

Do not let anyone else take your Actonel. Ask your pharmacist any questions you have about refilling your Aciphex prescription.

Where can I order Actonel from? Can I buy Actonel at Canadian prices?

Yes, if you are from the U.S. then you can buy Actonel at Canadian prices. Currently we will only accept an order for Actonel from U.S. and Canadian residents. Both U.S. and Canadian residents require a prescription to purchase Actonel and when you order Actonel it will be shipped with express shipping.

Why is Actonel prescribed?

Although our bones seem solid and stable, they actually undergo constant renewal. Specialized cells called osteoclasts draw used calcium out of the bones while other cells called osteoblasts replace it. Especially after menopause, this process can get out of balance. Calcium starts to leach out of the bones faster than it can be replaced, leading to the brittle-bone disease called osteoporosis. Actonel combats this problem by reducing the activity of the osteoclasts and slowing the loss of calcium from the bones. It is prescribed for postmenopausal women, both to prevent osteoporosis and to strengthen the bones once the disease has begun. It is also used to prevent or treat osteoporosis resulting from therapy with steroid medications, and it is used in the treatment of Paget's disease, a condition in which patches of bone become softened and enlarged.

Both Actonel and a similar drug called Fosamax are members of the family of drugs called bisphosphonates.

Most important fact about Actonel

Actonel not only stops the bone loss of osteoporosis, but actually reverses the disease and increases bone mineral density. As the bones grow stronger, your chances of sustaining a fracture decline.

How should you take Actonel?

Two types of Actonel are available: a 5-milligram Actonel tablet that's taken daily, and a 35-milligram tablet that's taken once a week. The tablets should be taken at least 30 minutes before the first food or drink of the day other than water. Take the pill while standing or sitting in an upright position and wash it down with a full 6 to 8 ounce glass of plain water (do not use coffee, tea, juice, milk, or other dairy products). Swallow the tablet whole, do not chew or suck on it. Do not lie down for 30 minutes after taking the medication. Other treatment measures typically include weight-bearing exercise, reduction of excessive smoking and drinking, and supplemental calcium and vitamin D if you don't get enough in your diet. If you require calcium supplements, or use any medications containing calcium, aluminum, or magnesium, avoid taking them at the same time of day as Actonel. --If you miss a dose...If you realize that you missed a daily dose and have not yet had anything to eat or drink, it's okay to take your medication. If you have already eaten, skip the dose for that day and take your regular dose the following morning. If you forget to take a weekly dose, take 1 tablet on the morning after you remember, then return to taking 1 tablet a week as originally scheduled on the chosen day. Never take 2 Actonel tablets on the same day. --Storage instructions...

Store Actonel at room temperature.

What Actonel side effects may occur?

Actonel Side effects cannot be anticipated. If any develop or change in intensity, inform your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking Actonel.

More common Actonel side effects may include:
Abdominal pain, anxiety, back pain, belching, bladder irritation, bone disorders and pain, bronchitis, bursitis, cataracts, chest pain, colitis, constipation, depression, diarrhea, difficulty breathing, dizziness, dry eyes, eye infection, flu-like symptoms, gas, headache, high blood pressure, infection, insomnia, itching, joint disorders and pain, leg cramps, muscle pain, muscle weakness, nausea, neck pain, nerve pain, pain, pneumonia, rash, ringing in ears, sinus problems, sore throat, stomach bleeding, stuffy or runny nose, swelling, tendon problems, tumor, ulcers, urinary tract infection, vertigo, vision problems, weakness

Less common Actonel side effects may include:
Anemia, angina, burning or prickly sensation, dental problems, ear infection, gastrointestinal distress, heart problems, hernia, rectal problems, skin cancer, stomach inflammation, tight muscles

Possible food and drug interactions when taking Actonel

If Actonel is taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your doctor before combining Actonel with the following:
Antacids
Calcium supplements
Laxatives such as Milk of Magnesia

Special Actonel information if you are pregnant or breastfeeding

Actonel has caused harm when tested on pregnant animals. It is not recommended during human pregnancy unless its benefits are judged to outweigh the potential risks. If you are pregnant or plan to become pregnant, notify your doctor immediately.

If you are nursing a baby, you'll need to choose between discontinuing nursing or discontinuing the drug.

Recommended Actonel dosage

ADULTS

Osteoporosis For the prevention and treatment of osteoporosis, the recommended dose is one 5-milligram tablet once daily or one 35-milligram tablet once a week. Steroid-Induced Osteoporosis For treatment or prevention of steroid-induced osteoporosis, the recommended dose is one 5-milligram tablet once a day. Paget's Disease

The recommended dose for Paget's disease is 30 milligrams once a day for two months. A second 2-month course of therapy may be required in certain individuals.

Actonel Overdosage

A large overdose of Actonel can dramatically reduce calcium levels in the blood. Warning signs include a tingling sensation and spasms. If you suspect an overdose, seek medical attention immediately.

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