ACTOS DESCRIPTION
Actos
ACTOS (pioglitazone hydrochloride) is an oral antidiabetic agent that acts primarily by decreasing insulin resistance. ACTOS is used in the management of type 2 diabetes mellitus (also known as non-insulin-dependent diabetes mellitus [NIDDM] or adult-onset diabetes). Pharmacological studies indicate that ACTOS improves sensitivity to insulin in muscle and adipose tissue and inhibits hepatic gluconeogenesis. ACTOS improves glycemic control while reducing circulating insulin levels.
Pioglitazone [(±)-5-[[4-[2-(5-ethyl-2-pyridinyl)ethoxy]phenyl]methyl]-2,4-] thiazolidine-dione monohydrochloride belongs to a different chemical class and has a different pharmacological action than the sulfonylureas, metformin, or the a-glucosidase inhibitors. The molecule contains one asymmetric carbon, and the compound is synthesized and used as the racemic mixture. The two enantiomers of pioglitazone interconvert in vivo. No differences were found in the pharmacologic activity between the two enantiomers.
Pioglitazone hydrochloride is an odorless white crystalline powder that has a molecular formula of C19H20N2O3S•HCl and a molecular weight of 392.90 daltons. It is soluble in water.
Where can I order Actos from? Can I buy Actos at Canadian prices?
Yes, if you are from the U.S. then you can buy Actos at Canadian prices. Currently we will only accept an order for Actos from U.S. and Canadian residents. Both U.S. and Canadian residents require a prescription to purchase Actos and when you order Actos it will be shipped with express shipping.
Why is Actos prescribed?
Actos is used to control high blood sugar in type 2 diabetes. This form of the illness usually stems from the body's inability to make good use of insulin, the natural hormone that helps to transfer sugar out of the blood and into the cells, where it's converted to energy. Actos works by improving the body's response to its natural supply of insulin, rather than increasing its insulin output. Actos also reduces the production of unneeded sugar in the liver.
Actos (and the similar drug Avandia) can be used alone or in combination with insulin injections or other oral diabetes medications such as DiaBeta, Micronase, Glucotrol, or Glucophage.
How should you take Actos?
Actos should be taken once a day with or without meals. --If you miss a dose...Take it as soon as you remember. If you miss a dose on one day, skip it and go back to your regular schedule. Do not double your dose the following day. --Storage instructions...
Store Actos at room temperature in a tight container, away from moisture and humidity.
What Actos side effects may occur?
Actos Side effects cannot be anticipated. If any develop or change in intensity, inform your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking Actos.
More common Actos side effects may include:
Headache, hypoglycemia, muscle aches, respiratory tract infection, sinus inflammation, sore throat, swelling, tooth disorder
Less common Actos side effects may include:
Anemia, shortness of breath, weight gain
Why should Actos not be prescribed?
If Actos gives you an allergic reaction, you should not take this drug.
Possible food and drug interactions when taking Actos
It is possible that Actos may reduce the effectiveness of birth control pills containing ethinyl estradiol and norethindrone. To guard against an unwanted pregnancy, be sure to use some other form of contraception.
If Actos is taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your doctor before combining Actos with the following:
Ketoconazole (Nizoral)
Midazolam (Versed)
Special Actos information if you are pregnant or breastfeeding
The effects of Actos during pregnancy have not been adequately studied. If you are pregnant or plan to become pregnant, tell your doctor immediately. He may switch you to insulin during your pregnancy, since normal blood sugar levels are very important for the developing baby.
It is not known whether Actos appears in breast milk. For safety's sake, do not use this drug while breastfeeding.
Recommended Actos dosage
ADULTS
The recommended starting dose of Actos is 15 to 30 milligrams once a day. If this fails to bring your blood sugar under control, the dose can be increased to a maximum of 45 milligrams a day. If your blood sugar still remains high, the doctor may add a second medication.
When Actos is added to other diabetes medications, your doctor may need to lower their dosage if you develop low blood sugar. If you are taking insulin, the dose should be lowered when blood sugar readings fall below 100.
Actos Overdosage
The effects of a massive Actos overdose are unknown, but any medication taken in excess can have serious consequences. If you suspect an overdose with Actos, seek medical attention immediately.
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