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Baclofen information for people that are required to take this medicine
Intrathecal means a kind of device that introduces small amounts of medications in the spinal fluid. One of the drugs who use intrathecal method is Baclofen. This medicine is used to treat the symptoms of the diseases like multiple sclerosis, tic doloroux, and spinal injuries. There are three common steps being done if you use this method.
These are as follows:
1-Initial screening bolus (fast induction of medicine), 50 mcg/mL of Baclofen is given to you and you will be observed for 4-8 hrs. This result will be positive if you will show signs of decrease in muscle tone and less muscle spasms. If your response is inadequate then a second bolus dose of 75 mcg/mL will be given. After 4-8 hrs, if result is still insufficient the final bolus of 100 mcg/mL will be given and observed for 24 hrs.
2-Postimplant dose titration, this is done to determine the correct dosage to be given to you. The boluses given to you will decide on how much your body will need to use for effectiveness. If your response in the drug lasted for more than 12 hrs then you’ll be prescribed for the same doses that you had in the screening. This will be administered to you within 24 hrs. After 1 day, your dosed will be increased from 10-30% until the desired affect is reached.
3-Maintenance therapy, in this step your Baclofen dose may be adjusted in the first few months of treatment. The dose will be increased as the therapy goes, but if reactions occur it will be decreased in 10-20%. You should use the lowest dose producing positive effects for your wellbeing.
Abrupt withdrawal of intrathecal use will result to high fever, disorientation, muscle rigidity, multiple organ failure and even death. Discontinuation of therapy should be slowly but surely. You should identify symptoms that require immediate actions. Call your doctor any unusual effects happening.
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