CIMETIDINE DESCRIPTION

Cimetidine - Tablet

Cimetidine is a histamine blocker used to treat and prevent ulcers. It is also used to treat gastroesophageal reflux disease (GERD). This medicine may also be used to treat other conditions as determined by your doctor.

Why is Cimetidine prescribed?

Cimetidine is prescribed for the treatment of certain kinds of stomach and intestinal ulcers and related conditions. These include: active duodenal (upper intestinal) ulcers; active benign stomach ulcers; erosive gastroesophageal reflux disease (backflow of acid stomach contents); prevention of upper abdominal bleeding in those who are critically ill; and excess-acid conditions such as Zollinger-Ellison syndrome (a form of peptic ulcer with too much acid). It is also used for maintenance therapy of duodenal ulcer following the healing of active ulcers. Cimetidine is known as a histamine blocker. Some doctors also use Cimetidine to treat acne and to prevent stress-induced ulcers. It may also be used to treat chronic hives, herpesvirus infections (including shingles), abnormal hair growth in women, and overactivity of the parathyroid gland.

Cimetidine HB is an over-the-counter version of the drug used to relieve heartburn, acid indigestion, and sour stomach.

Most important fact about Cimetidine

Short-term treatment with Cimetidine can result in complete healing of a duodenal ulcer. However, there can be a recurrence of the ulcer after Cimetidine has been discontinued. The rate of ulcer recurrence may be slightly higher in people healed with Cimetidine rather than other forms of therapy. However, Cimetidine is usually prescribed for more severe cases.

How should you take Cimetidine?

You can take Cimetidine with or between meals. Do not take antacids within 1 to 2 hours of a dose of Cimetidine. Avoid excessive amounts of caffeine while taking this drug. It may take several days for Cimetidine to begin relieving stomach pain. Be sure to continue taking the drug exactly as prescribed even if it seems to have no effect. Do not take the maximum daily dose of Cimetidine HB for more than 2 weeks continuously without consulting your doctor. --If you miss a dose...Take it as soon as you remember. If it is almost time for your next dose, skip the one you missed and go back to your regular schedule. Do not take 2 doses at once. --Storage instructions...Store at room temperature in a tightly closed container, away from light.

What side effects may occur with Cimetidine ?

Cimetidine Side effects cannot be anticipated. If any develop or change in intensity, inform your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking Cimetidine.

More common Cimetidine side effects may include:
Breast development in men, headache

Less common Cimetidine side effects--agitation, anxiety, confusion, depression, disorientation, and hallucinations--may appear in severely ill individuals who have been treated for 1 month or longer. However, these reactions are not permanent and have cleared up within 3 to 4 days of discontinuation of the drug.

Rare Cimetidine side effects may include:
Allergic reactions, anemia, blood disorders, diarrhea, dizziness, fever, hair loss, impotence, inability to urinate, joint pain, kidney disorders, liver disorders, mild rash, muscle pain, pancreas inflammation, rapid heartbeat, skin inflammation or peeling, sleepiness, slow heart beat

Why should Cimetidine not be prescribed?

If you have ever had an allergic reaction to Cimetidine, do not take this medication.

Special warnings about Cimetidine

Ulcers may be more difficult to heal if you smoke cigarettes. If you are being treated for a liver or kidney disorder, make sure the doctor is aware if it. If you are over 50 years old, have liver or kidney disease, or are severely ill, you may experience temporary mental confusion while taking Cimetidine. Notify your doctor.

If you have trouble swallowing or persistent abdominal pain, do not take Cimetidine HB; instead, check with your doctor. You may have a serious condition that requires different treatment.

Possible food and drug interactions when taking Cimetidine

If Cimetidine is taken with certain other drugs, the effects of either can be increased, decreased, or altered. It is especially important that you check with your doctor before combining Cimetidine with the following:

Antidiabetic drugs such as Micronase and Glucotrol
Antifungal drugs such as Diflucan and Nizoral
Aspirin
Augmentin
Benzodiazepine tranquilizers such as Valium and Librium
Beta-blocking blood pressure drugs such as Inderal and Lopressor
Calcium-blocking blood pressure drugs such as Cardizem, Calan, and Procardia
Chlorpromazine (Thorazine)
Cisapride (Propulsid)
Cyclosporine (Sandimmune)
Digoxin (Lanoxin)
Medications for irregular heartbeat, such as Cordarone, Tonocard, Quinidex, and Procan
Metoclopramide (Reglan)
Metronidazole (Flagyl)
Narcotic pain relievers such as Demerol and Morphine
Nicotine (Nicoderm, Nicorette)
Paroxetine (Paxil)
Pentoxifylline (Trental)
Phenytoin (Dilantin)
Quinine
Sucralfate (Carafate)
Theophylline (Theo-Dur, others)
Warfarin (Coumadin)
Avoid alcoholic beverages while taking Cimetidine. This medication increases the effects of alcohol. Antacids can reduce the effect of Cimetidine when taken at the same time. If you take an antacid to relieve the pain of an ulcer, the doses should be separated by 1 to 2 hours.

If you need to take an antifungal drug such as Nizoral, you should take it at least 2 hours before you take Cimetidine.

Special information if you are pregnant or breastfeeding when taking Cimetidine

The effects of Cimetidine during pregnancy have not been adequately studied. If you are pregnant or plan to become pregnant, notify your doctor immediately. Cimetidine appears in breast milk and could affect a nursing infant. If this medication is essential to your health, your doctor may advise you to discontinue breastfeeding until treatment with this drug is finished.

Recommended Cimetidine dosage

Cimetidine (ADULTS)

Active Duodenal UlcerThe usual dose is 800 milligrams once daily at bedtime. However, other doses shown to be effective are: 300 milligrams 4 times a day with meals and at bedtime 400 milligrams twice a day, in the morning and at bedtime Most people heal in 4 weeks. If you require maintenance therapy, the usual dose is 400 milligrams at bedtime. Active Benign Gastric UlcerThe usual dose is 800 milligrams once a day at bedtime or 300 milligrams taken 4 times a day with meals and at bedtime. Erosive Gastroesophageal Reflux DiseaseThe usual dosage is a total of 1,600 milligrams daily divided into doses of 800 milligrams twice a day or 400 milligrams 4 times a day for 12 weeks. The beneficial use of Cimetidine beyond 12 weeks has not been firmly established. Pathological Hypersecretory ConditionThe usual dosage is 300 milligrams 4 times a day with meals and at bedtime. Your doctor may adjust your dosage based on your needs, but you should take no more than 2,400 milligrams per day.

Cimetidine (CHILDREN) Safety and effectiveness have not been established in children under 16 years old. However, your doctor may decide that the potential benefits of Cimetidine use outweigh the potential risks. Doses of 20 to 40 milligrams per 2.2 pounds of body weight have been used.

Heartburn, acid indigestion, sour stomachThe usual dosage is 2 tablets, taken with water, once or up to twice a day. Do not take more than 4 tablets in 24 hours.

Do not give Cimetidine HB to children under 12 years unless your doctor tells you to.

Cimetidine Overdosage

Information concerning overdosage is limited. However, respiratory failure, an increased heartbeat, exaggerated side effect symptoms or reactions such as unresponsiveness may be signs of Cimetidine overdose. If you experience any of these symptoms, notify your doctor immediately.

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