COMTAN DESCRIPTION

Comtan (Entacapone)

Comtan is manufactured by Novartis. Comtan is a catechol-o-methyltransferase (COMT) inhibitor used along with levodopa/carbidopa to treat Parkinson's disease.

Ingredient
Entacapone

Caution
Some medicines or medical conditions may interact with this medicine. INFORM YOUR DOCTOR OR PHARMACIST of all prescription and over-the-counter medicine that you are taking. DO NOT TAKE THIS MEDICINE if you are also taking phenelzine or tranylcypromine. ADDITIONAL MONITORING OF YOUR DOSE OR CONDITION may be needed if you are taking isoproterenol or bitolterol. Inform your doctor of any other medical conditions, allergies, pregnancy, or breast-feeding. Contact your doctor or pharmacist if you have any questions or concerns about taking this medicine.

DO NOT STOP USING THIS MEDICINE without first checking with your doctor. KEEP ALL DOCTOR AND LABORATORY APPOINTMENTS while you are using this medicine. BEFORE YOU HAVE ANY MEDICAL TREATMENTS, EMERGENCY CARE, OR SURGERY, tell the doctor that you are using this medicine. THIS MEDICINE MAY CAUSE DIZZINESS, lightheadedness, or fainting. Alcohol, hot weather, exercise, and fever can increase these effects. To prevent them, sit up or stand slowly, especially in the morning. Also, sit or lie down at the first sign of dizziness, lightheadedness, or weakness. DO NOT DRIVE, OPERATE MACHINERY, OR DO ANYTHING ELSE THAT COULD BE DANGEROUS until you know how you react to this medicine. Using this medicine alone, with other medicines, or with alcohol may lessen your ability to drive or to perform other potentially dangerous tasks. THIS MEDICINE MAY COLOR THE URINE brownish orange. This is normal. FOR WOMEN: IF YOU PLAN ON BECOMING PREGNANT, discuss with your doctor the benefits and risks of using this medicine during pregnancy. IT IS UNKNOWN IF THIS MEDICINE IS EXCRETED in breast milk. IF YOU ARE OR WILL BE BREAST-FEEDING while you are using

Where can I order Comtan From? Can I buy Comtan at Canadian Prices?

Yes, if you are from the U.S. then you can buy Comtan at Canadian prices. Currently we will only accept an order for Comtan from U.S. and Canadian residents. Both U.S. and Canadian residents require a prescription to purchase Comtan and when you order Comtan it will be delivered with express shipping.

Why is Comtan prescribed?

Comtan is used for Parkinson's disease. It is prescribed when doses of the combination drug levodopa/carbidopa (Sinemet) begin to wear off too soon. By extending the effect of each dose of Sinemet, it frees the patient from the stiffness and tremors of Parkinson's for a longer period of time.

Comtan works by inhibiting the effect of an enzyme that breaks down the levodopa in Sinemet. It has no effect on Parkinson's disease when used by itself.

Most important fact about Comtan

Comtan's value lies in its ability to extend Sinemet's effectiveness when it begins to decline. It is helpful only when taken with the other drug, and has no benefit when used alone.

How should you take Comtan?

Comtan should be taken with each dose of Sinemet. It can be taken up to 8 times per day, with or without food.--If you miss a dose...Take it along with a dose of Sinemet as soon as you remember. If it is almost time for your next dose, skip the one you missed and go back to your regular schedule. Never take 2 doses at the same time.--Storage instructions...

Store Comtan at room temperature.

What side effects may occur with Comtan?

Comtan Side effects cannot be anticipated. If any develop or change in intensity, inform your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking Comtan.

More common Comtan side effects may include:
Abdominal pain, back pain, constipation, diarrhea, discoloration of urine, dizziness, nausea, onset of new movement disorders, tired feeling, vomiting

Less common Comtan side effects may include:
Agitation, anxiety, bruises, difficulty breathing, dry mouth, gas, increased sweating, indigestion, infection, sleepiness, stomach distress, taste changes, weakness, worsening of Parkinson's disease

Why should Comtan not be prescribed?

If Comtan gives you an allergic reaction, you won't be able to use it. It is prescribed only with caution for people with liver disease.

Special warnings about Comtan

Use of Comtan can cause low blood pressure, with symptoms such as dizziness, nausea, fainting, and sweating. Be careful when standing up after you have been sitting or lying down. See how the medication affects you before you drive a car or operate machinery.Nausea and diarrhea are especially common side effects of Comtan, developing in more than 10 percent of those taking it. In rare cases, the problem is severe. Comtan may also cause hallucinations, and occasionally triggers new movement disorders. In about 10 percent of those taking it, it has the harmless side effect of turning the urine a brownish-orange color.An abrupt discontinuation of Comtan can cause a reappearance of Parkinson's symptoms. If a decision is made to discontinue the drug, it should be withdrawn slowly, under a doctor's supervision.

This drug is not intended for use in children.

Special information if you are pregnant or breastfeeding when taking Comtan

The possibility of damage to a developing baby has not been ruled out. Tell your physician immediately if you are pregnant or plan to become pregnant. Comtan may appear in breast milk. It should be used with caution if you are nursing your baby.

Recommended Comtan dosage

ADULTS The recommended dose is one 200-milligram tablet with each dose of Sinemet, up to a maximum of 8 doses per day. If you were taking more than 800 milligrams of levodopa per day before starting Comtan, you will probably need a reduction in your levodopa dose once you begin taking the drug.

Comtan Overdosage

Little is known about the result of Comtan overdose. However, the results could be serious, so if you suspect an overdose, seek medical attention immediately.

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