Diane 35 is manufactured by Shering. This medicine is an estrogen and progestin combination used to prevent pregnancy. It may also be used to regulate the menstrual cycle, treat symptoms of menopause, or treat other conditions as determined by your doctor.

Where can I order Diane 35 From? Can I buy Diane 35 at Canadian Prices?

Yes, if you are from the U.S. then you can buy Diane 35 at Canadian prices. Currently we will only accept an order for Diane 35 from U.S. and Canadian residents. Both U.S. and Canadian residents require a prescription to purchase Diane 35 and when you order Diane 35 it will be delivered with express shipping.

Brand Name
Diane-35

Common Name
cyproterone - ethinyl estradiol

How does Diane 35 work? What will it do for me?

Diane 35 contains a combination of two ingredients: cyproterone and ethinyl estradiol. Cyproterone belongs to a group of medications known as antiandrogens. Ethinyl estradiol belongs to a group of medications known as estrogens. Together, they are used to treat certain types of acne in women. Diane 35 works by regulating hormones that affect the skin.

Your doctor may have suggested Diane 35 for conditions other than the ones listed in these drug information articles. If you have not discussed this with your doctor or are not sure why you are taking Diane 35, speak to your doctor. Do not stop taking Diane 35 without consulting your doctor.

How should I use Diane 35?

Diane 35 is taken in 28-day cycles consisting of one tablet daily for 21 days, followed by a 7-day interval without medication (i.e., three weeks on, one week off). Tablets should be taken at the same time each day. Treatment is usually started on the first day of menstrual bleeding. Usually, several months of treatment are needed.

If spotting or breakthrough bleeding occurs during the three weeks during which Diane 35 is being taken, contact your doctor.

If your menstrual period fails to occur during the 7-day tablet-free interval, do not start the next medication cycle and contact your doctor.

Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are using the medication without consulting your doctor.

It is very important that Diane 35 be used on a regular schedule as prescribed by the doctor. The medication will be less effective if you miss doses. If you miss a dose of Diane 35, and you remember within 12 hours, take the missing dose. If more than 12 hours have passed, discard the missed tablet and continue to take the remaining tablets in the pack at the usual time. Do not double-up on doses.

What form(s) does Diane 35 come in?

Each beige, round, sugar-coated tablet contains cyproterone acetate 2 mg and ethinyl estradiol 0.035 mg. Nonmedicinal ingredients: cornstarch, lactose, magnesium stearate, povidone, and talc; tablet coating: calcium carbonate, ferric oxide yellow, glycerol, polyethylene glycol, povidone, sucrose, talc, titanium dioxide, and wax.
Who should NOT take Diane 35?

Diane 35 should not be used by people who:

are allergic to cyproterone, estradiol, or any ingredients of the medication
have existing or have had blood vessel or blood clotting disorders (including thrombophlebitis, thromboembolic disorders, cerebrovascular disease, heart attack, and coronary artery disease)
have active liver disease
have or have had liver tumours
have a history of cholestatic jaundice
have known or suspected breast cancer
have known or suspected tumours dependent on estrogen
have undiagnosed abnormal vaginal bleeding
have any eye lesion caused by blood vessel disease in the eye (such as partial or complete loss of vision or a defect in the visual fields)
have severe diabetes with blood vessel changes
have had otosclerosis with deterioration during pregnancy
are or may be pregnant

What side effects are possible with Diane 35?

The side effects listed below are not experienced by everyone who takes Diane 35. If you are concerned about side effects, discuss the risks and benefits of Diane 35 with your doctor. Your health professional may be able to help you deal with some of the effects.

The following side effects may go away as your body becomes used to the medication; check with your doctor if they continue or become bothersome.

More common:

nausea
vomiting
abdominal cramping or bloating
breast pain, tenderness, or swelling
dizziness
swelling of ankles and feet
unusual tiredness or weakness
Less common:

brown, blotchy spots on exposed skin
gain or loss of body or facial hair
increased or decreased interest in sexual intercourse
increased sensitivity of skin to sunlight
weight gain or loss
Check with your doctor as soon as possible if any of the following side effects occur:

More common (usually less common after the first three months of use):

changes in the uterine bleeding pattern during or between menstrual periods, such as decreased bleeding, breakthrough bleeding or spotting between periods, prolonged bleeding, complete stopping of menstrual bleeding that occurs over several months in a row, or stopping of menstrual bleeding that only occurs sometimes
Less common:

headaches or migraines (although headaches may lessen for many users, for others, they may increase in number or become worse)
increased blood pressure
vaginal infection with vaginal itching or irritation, or thick, white, or curd-like discharge
for women with diabetes: mild increase of blood sugar-faintness, nausea, pale skin, or sweating
Rare:

depression
swelling, pain, or tenderness in upper abdominal area
for women who smoke tobacco: pains in stomach, side, or abdomen; yellow eyes or skin
for women with a history of breast disease: lumps in breast
Get emergency medical help immediately if any of the following side effects occur:

Rare:

abdominal or stomach pain (sudden, severe, or continuing)
coughing-up of blood
headache (severe or sudden)
loss of coordination (sudden)
loss of vision or change in vision (sudden)
pains in chest, groin, or leg (especially in calf of leg)
shortness of breath (sudden or unexplained)
slurring of speech (sudden)
weakness, numbness, or pain in arm or leg (unexplained)
Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking Diane 35.

Are there any other precautions or warnings for Diane 35?

Birth control: Diane 35 should not be used only for the purpose of birth control. Women should use a non-hormonal method of birth control (such as condoms) while taking Diane 35.

Breast cancer: All women who take Diane 35 should practice breast self-examination. Ask your doctor to teach you how to do this. Women with a family history of breast cancer should be closely monitored by their doctor while taking Diane 35.

Medical conditions: The combination of obesity, high blood pressure, and diabetes greatly increases the risk of side effects from Diane 35. If you have this combination of medical conditions, talk to your doctor. Diane 35 can cause fluid retention, which may worsen conditions such as high blood pressure, heart disease, or kidney disease.

Smoking: Smoking increases the risk of serious side effects on the heart and blood vessels. This risk increases with age and heavy smoking (15 or more cigarettes per day) and is even more serious for women over 35 years of age. Women who use Diane 35 should not smoke.

Vaginal bleeding: Report any unusual vaginal bleeding to your doctor.

Vision and contact lenses: If your contact lenses do not seem to fit as well as they used to, consult your doctor or eye care professional. You may need to stop wearing them, or be fitted for a different pair.

Pregnancy: Diane 35 should not be taken by pregnant women. If you are or may be pregnant, stop taking the medication and talk to your doctor as soon as possible. After stopping treatment, you should wait until at least one normal menstrual cycle has occurred before trying to get pregnant.

Surgery: If you are scheduled for surgery, let all doctors involved in your care know that you are taking Diane 35.

Breast-feeding: Women who are using Diane 35 should not breast-feed.

What other drugs could interact with Diane 35?

The following medications may affect how Diane 35 works, be affected by Diane 35, or increase the risk of side effects:
ampicillin
analgesics (painkillers; e.g., codeine)
anti-diabetes medications (e.g., glyburide, gliclazide)
antihistamines (e.g., chlorpheniramine, loratidine)
anti-migraine medications (e.g., dihydroergotamine)
barbiturates (e.g., pentobarbital, secobarbital)
beta-blockers (e.g., metoprolol, atenolol)
blood pressure-lowering medications (e.g., hydrochlorothiazide)
caffeine
carbamazepine
certain benzodiazepines (e.g., alprazolam, clonazepam)
chloramphenicol
corticosteroids (e.g., prednisone)
griseofulvin
isoniazid
neomycin
nitrofurantoin
penicillin V
phenothiazines (e.g., chlorpromazine)
phenobarbital
phenylbutazone
phenytoin
primidone
rifampin
sulfonamides (e.g., sulfamethoxazole)
tetracycline
theophyllines (e.g., aminophylline, oxtriphylline, theophylline)
topiramate
tricyclic antidepressants (e.g., amitriptyline, desipramine)
warfarin
vitamin C (ascorbic acid)

If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:

stop taking one of the medications,
change one of the medications to another,
change how you are taking one or both of the medications, or
leave everything as is.
An interaction between two medications does not always mean that you must stop taking one of them. In many cases, interactions are intended or are managed by close monitoring. Speak to your doctor about how any drug interactions are being managed or should be managed.

Medications other than those listed above may interact with Diane 35. Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications that you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.

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