ESTRACE DESCRIPTION
Estradiol Vaginal Cream Compounded
Estrace is compounded locally.
Brand Name
Estrace
Common Name
estradiol-17ß (micronized)
Where can I order Estrace From? Can I buy Estrace at Canadian Prices?
Yes, if you are from the U.S. then you can buy Estrace at Canadian prices. Currently we will only accept an order for Estrace from U.S. and Canadian residents. Both U.S. and Canadian residents require a prescription to purchase Estrace and when you order Estrace it will be delivered with express shipping.
How does Estrace work? What will it do for me?
Estrace (micronized) belongs to the class of medications known as estrogen replacement therapy. Estrogen is a female hormone produced by the ovaries. Once menopause is reached, the ovaries produce less estrogen and progesterone (another hormone) and symptoms of menopause can occur.
Estrace (micronized) is an estrogen replacement hormone used for the management of menopausal symptoms such as abnormal uterine bleeding, hot flashes, sweating, and chills. It may also contribute to the prevention of osteoporosis in women when combined with diet, calcium, and exercise. Women who have not had a hysterectomy must also take a progestogen while they are taking Estrace.
Your doctor may choose to use a medication for conditions other than the ones listed in these drug information articles. If you're unsure why you are taking Estrace, contact your doctor.
How should I use Estrace?
Typically, estrogen is taken for the first 21 to 25 days of each month. Women who have not had a hysterectomy (i.e., they still have a uterus) should take a progestogen (e.g., medroxyprogesterone) for the last 12 to 14 days of each estrogen cycle.
For treatment of menopausal symptoms, the usual dose is 1 mg daily for 21 to 25 days of each month. Attempts to discontinue the medication should be made every three to six months. If symptoms return, the medication should be continued.
For prevention of osteoporosis, the usual dose is 0.5 mg daily as soon as possible after the onset of menopause. The dose may be increased or decreased according to the level of estradiol in the blood.
Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.
It is very important that Estrace be taken on a regular schedule as prescribed by the doctor. If you miss a dose of Estrace take it as soon as you remember it. If it is almost time for your next dose, skip the missed dose and carry on with your regular schedule. Do not double-up on doses.
Who should NOT take Estrace?
Estrace should not be used by anyone who:
has liver dysfunction or disease, especially of the obstructive type
has or has had breast cancer or endometrial cancer, except in special circumstances
has endometrial hyperplasia
has a known or suspected estrogen-dependent tumour
has undiagnosed vaginal bleeding
has had a stroke
has had coronary thrombosis
has had migraine headaches
has had diseases of circulation or clotting
has had partial or complete loss of vision or double-vision from eye disease related to circulation problems
has endometriosis or leiomyoma of the uterus
is or may be pregnant
is breast-feeding
is allergic to any ingredient of the medication
What side effects are possible with Estrace?
The side effects listed below are not experienced by everyone who takes Estrace. If you are concerned about side effects, discuss the risks and benefits of Estrace with your doctor. Your health professional may be able to help you deal with some of the effects.
The following side effects may go away as your body becomes used to the medicine; check with your doctor if they continue or become bothersome.
More common:
bloating of stomach
cramps of lower stomach
loss of appetite
nausea
Less common:
diarrhea (mild)
dizziness (mild) headaches (mild)
migraine headaches
problems with wearing contact lenses
unusual increase in sexual desire
vomiting (usually with high doses)
Check with your doctor as soon as possible if any of the following side effects occur:
More common:
breast pain
increased breast size
swelling of feet and lower legs weight gain (rapid)
Less common or rare:
changes in vaginal bleeding (spotting, breakthrough bleeding, prolonged or heavier bleeding, or complete stoppage of bleeding)
lumps in or discharge from the breasts
pains in stomach, side, or abdomen
yellowing of eyes or skin
Check with your doctor immediately if any of the following side effects occur:
Rare:
headache (sudden or severe) loss of coordination (sudden)
loss of vision or change of vision (sudden)
pains in chest, groin, or leg, especially in the calf of leg
shortness of breath (sudden and unexplained)
slurring of speech (sudden)
weakness or numbness in arm or leg
Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking Estrace.
Are there any other precautions or warnings for Estrace?
Endometrial cancer: There is evidence from several studies that estrogen replacement therapy increases the risk of cancer of the endometrium (uterus). Taking a progestogen appropriately along with the estrogen reduces this risk to the same level as that of a woman who does not take estrogen. For this reason, all women who have not had their uteruses removed should also take progestogen if they use estrogens.
Breast cancer: Studies indicate an increased risk of breast cancer with long-term use of estrogen replacement therapy. Women who have breast nodules, fibrocystic disease, abnormal mammograms, or a strong family history of breast cancer should approach the use of estrogens with particular caution. Women who take estrogens should have regular breast examinations and should be instructed in breast self-examination.
Blood problems: Estrogens should not be used by persons with active thrombophlebitis or thromboembolic disorders (diseases of blood clotting and abnormal circulation). They should also not be used (except in the treatment of cancer) by persons with a history of such disorders in association with estrogen use. Finally, they should be used with caution by people with cerebral vascular disease or coronary artery disease and only used if clearly needed.
Some studies have suggested that, for healthy women, there is an increased relative risk of developing deep vein thrombosis or pulmonary embolism when on hormone replacement therapy. Women with severe varicose veins or severe obesity, and those needing to stay in bed for 3 weeks or more, are generally considered to be at increased risk of venous thromboembolism (blood clots in the bloodstream).
Increased blood pressure is not uncommon for women using Estrace. Blood pressure should be monitored with estrogen use, especially if high doses are used.
Smoking can increase the risk of blood clots. Women taking estrogen are strongly advised not to smoke.
Diabetes: Estrogens may affect blood sugar control. Anyone with diabetes should carefully monitor their blood glucose levels while taking any medication containing estrogen.
Gallbladder disease: An increased risk of gallbladder disease has been reported in postmenopausal women who take estrogens.
Fluid retention: Estrogen may cause sodium (salt) and fluid retention. Women with heart or kidney dysfunction, epilepsy, or asthma should be particularly careful when taking it.
Cholesterol: Oral estrogens can increase triglycerides in the blood. Your physician may check your cholesterol while on estrogen.
Fibroids: Estrace may worsen fibroids, causing sudden enlargement, pain, or tenderness. If you notice these effects, contact your doctor.
Pregnancy: Estrogen should not be used during pregnancy. If you become pregnant while taking Estrace, contact your doctor.
Breast-feeding: Estrogen is not safe for use during breast-feeding. A decision should be made whether to discontinue nursing or to discontinue the medication, taking into account the importance of the medication to the mother.
Children: The safety and effectiveness of Estrace have not been established for use by children.
What other drugs could interact with Estrace?
The following medications may affect how estradiol works or increase the risk of side effects:
barbiturates (e.g., phenobarbital)
carbamazepine
meprobamate
phenylbutazone
phenytoin
protease inhibitors (e.g., ritonavir)
rifampin
topiramate
The following medications may be affected by estradiol:
antidiabetic agents (e.g., insulin, glyburide)
blood pressure-lowering agents (e.g., propranolol, enalapril, diltiazem)
corticosteroids (hydrocortisone, prednisolone, prednisone)
warfarin
If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:
stop taking one of the medications,
change one of the medications to another,
change how you are taking one or both of the medications, or
leave everything as is.
An interaction between two medications does not always mean that you must stop taking one of them. In many cases, interactions are intended or are managed by close monitoring. Speak to your doctor about how any drug interactions are being managed or should be managed.
Medications other than those listed above may interact with Estrace. Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications that you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.
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