Leukeran is an alkylating agent used to treat certain cancers. It may also be used to treat other conditions as determined by your doctor. Directions: How to use this Medicine: Follow the directions for using this medicine provided by your doctor. TRY TO TAKE THIS MEDICINE at the same time every day. DRINKING EXTRA FLUIDS while you are taking this medicine is recommended. Check with your doctor or nurse for instructions. IF NAUSEA, VOMITING, OR LOSS OF APPETITE OCCURS, ask your doctor, nurse, or pharmacist for ways to lessen these effects. STORE THIS MEDICINE in the refrigerator between 36 and 46 degrees F (2 and 8 degrees C). IF YOU MISS A DOSE OF THIS MEDICINE and you take 1 dose daily, take the missed dose if you remember the same day. Skip the missed dose if you do not remember until the next day. Do not take 2 doses at once. Side Effects: Possible Side Effects: SIDE EFFECTS, that may go away during treatment, include diarrhea, tiredness, or mild nausea. If they continue or are bothersome, check with your doctor. CHECK WITH YOUR DOCTOR AS SOON AS POSSIBLE if you experience fever; chills; sore throat; hip, stomach or joint pain; vomiting; yellowing of the skin or eyes; sores in the mouth or on the lips; persistent cough; congestion, shortness of breath, or difficulty breathing; unusual bruising or bleeding; absence of monthly period; excessive tiredness; swelling; hives; or skin rash. If you notice other effects not listed above, contact your doctor, nurse, or pharmacist. Ingredient Chlorambucil Caution DO NOT EXCEED THE DOSE prescribed by your doctor. KEEP ALL DOCTOR AND LABORATORY APPOINTMENTS while you are taking this medicine. THIS MEDICINE LOWERS YOUR RESISTANCE to infection. To prevent infection, avoid contact with people who have colds or other infections. Do not touch your eyes or the inside of your nose unless you have thoroughly washed your hands first. THIS MEDICINE MAY REDUCE THE NUMBER OF BLOOD CELLS NEEDED FOR CLOTTING. To prevent bleeding, avoid situations where bruising or injury may occur. CHECK WITH YOUR DOCTOR BEFORE HAVING IMMUNIZATIONS (VACCINATIONS) while you are using this medicine. THE USE OF BIRTH CONTROL IS RECOMMENDED while you are taking this medicine. THIS MEDICINE HAS BEEN SHOWN TO CAUSE HARM to the human fetus. IF YOU PLAN ON BECOMING PREGNANT, discuss with your doctor the benefits and risks of using this medicine during pregnancy. IT IS UNKNOWN IF THIS DRUG IS EXCRETED in breast milk. DO NOT BREAST-FEED while taking this medicine.

 

Most important fact about Leukeran

Leukeran may cause bladder damage, probably from toxic byproducts of the drug that are excreted in the urine. Potential problems include bladder infection with bleeding and fibrosis of the bladder.

While you are being treated with Leukeran , drink 3 or 4 liters of fluid a day to help prevent bladder problems. The extra fluid will dilute your urine and make you urinate frequently, thus minimizing the Leukeran byproducts' contact with your bladder.

Where can I order Leukeran from? Can I buy Leukeran at Canadian Prices?

Yes, if you are from the U.S. then you can buy Leukeran at Canadian prices. Currently we will only accept an order for Leukeran from U.S. and Canadian residents. Both U.S. and Canadian residents require a prescription to purchase Leukeran and when you order Leukeran it will be delivered with express shipping.

How should you take Leukeran ?

Take Leukeran exactly as prescribed. You will undergo frequent blood tests, and the doctor will adjust your dosage depending on your white blood cell count; a dosage reduction is necessary if the count drops below a certain level. You will also have frequent urine tests to check for blood in the urine, a sign of bladder damage. Take Leukeran on an empty stomach. If you have severe stomach upset, then you may take it with food. If you are unable to swallow the tablet form, you may be given an oral solution made from the injectable form of Leukeran and Aromatic Elixir. This solution should be used within 14 days. ---If you miss a dose...Do not take the dose you missed. Go back to your regular schedule and contact your doctor. Do not take 2 doses at once. ---Storage instructions...

Store tablets at room temperature. Store the oral solution in the refrigerator.

What side effects may occur with Leukeran ?

Side effects cannot be anticipated. If any develop or change in intensity, inform your doctor immediately. Only your doctor can determine if it is safe for you to continue using Leukeran . One possible Leukeran side effect is the development of a secondary cancer, typically of the bladder, lymph nodes, or bone marrow. A secondary cancer may occur up to several years after the drug is given. Leukeran can lower the activity of your immune system, making you more vulnerable to infection. Noncancerous bladder problems may occur during Leukeran therapy (see "Most important fact about this drug" section, above).

More common side effects may include:
Loss of appetite, nausea and vomiting, temporary hair loss

Less common or rare side effects may include:
Abdominal pain, anemia, bleeding, darkening of the skin and changes in fingernails, decreased sperm count, diarrhea, fever, infections, infertility, lung infections, missedmenstrual periods, mouth sores, new tumor growth, other cancers, rash, severe allergic reaction, slow wound healing, yellowing of eyes and skin

Why should Leukeran not be prescribed?

Do not take this medication if you have ever had an allergic reaction to it. Also, tell your doctor if you have ever had an allergic reaction to another anticancer drug such as Alkeran, CeeNU, Emcyt, Leukeran, Myleran, or Zanosar. In adults, Leukeran should not be given for "minimal change" nephrotic syndrome or any other kidney disease.

Also, Leukeran should not be given to anyone who is unable to produce normal blood cells because the bone marrow---where blood cells are made---is not functioning well.

Special information if you are pregnant or breastfeeding while taking Leukeran

If you are pregnant or plan to become pregnant, inform your doctor immediately. When taken during pregnancy, Leukeran can cause defects in the unborn baby. Women taking Leukeran should use effective contraception. Leukeran does appear in breast milk. A new mother will need to choose between taking this drug and nursing her baby.

Recommended Leukeran dosage

ADULTS AND CHILDREN

Malignant Diseases
Your doctor will tailor your dosage according to your condition and other drugs taken with Leukeran . The recommended oral dosage range is 1 to 5 milligrams per 2.2 pounds of body weight per day.

CHILDREN

"Minimal Change" Nephrotic Syndrome
The recommended oral dosage is 2.5 to 3 milligrams per 2.2 pounds of body weight per day for a period of 60 to 90 days.

Leukeran Overdosage

Although there is no specific information on Leukeran overdose, any medication taken in excess can have serious consequences. If you suspect an overdose of Leukeran , seek medical attention immediately.

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