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Megestrol is mMegestrol is a man-made substance called a progestin which is similar to the female hormone progesterone. It is a type of drug known as hormonal therapy. Megestrol is mainly used in the treatment of breast cancer. Its other uses are described at the end of this factsheet.
Caution
SIDE EFFECTS, that may go away during treatment, include changes in appetite, thirst, or weight; headache; indigestion; or breast tenderness. If they continue or are bothersome, check with your doctor. CHECK WITH YOUR DOCTOR AS SOON AS POSSIBLE if you experience unexplained vaginal bleeding, swelling of ankles or fingers, rash, leg pain, difficulty breathing, nausea, vomiting, or dizziness. If you notice other effects not listed above, contact your doctor, nurse, or pharmacist
Brand Name
Megace
Common Name
megestrol acetate
Where can I order Megestrol from? Can I buy Megestrol at Canadian Prices?
Yes, if you are from the U.S. then you can buy Megestrol at Canadian prices. Currently we will only accept an order for Megestrol from U.S. and Canadian residents. Both U.S. and Canadian residents require a prescription to purchase Megestrol and when you order Megestrol it will be delivered with express shipping.
How does Megestrol work? What will it do for me?
Megestrol belongs to a group of medicines known as progestagens. It prevents the release of a hormone required for production of testosterone in the testicles.
Megestrol is used to treat prostate cancer, because testosterone is needed by prostate cancer cells for growth.
Megestrol also slows the growth of breast and endometrium (lining of the uterus) cancer cells by interfering with other hormones and proteins that are required for growth of the cancer cells.
Megestrol is also used for the treatment of appetite loss and severe weight or muscle loss in people with cancer or acquired immunodeficiency syndrome (AIDS). It helps these conditions by promoting the production of certain proteins that increase appetite and weight gain.
Your doctor may choose to use Megestrol for other conditions not listed here. If you're unsure why you are taking Megestrol, please ask your doctor.
How should I use Megestrol?
The recommended dose depends on the disease being treated and body size.
For prostate cancer, the recommended dose is 120 mg as a single daily dose in combination with diethylstilbestrol 0.1 mg.
For breast cancer, the usual dose is 160 mg daily. This dose may be divided into four equal doses of 40 mg.
For cancer of the endometrium, the usual dose is 80 mg to 320 mg daily, which can be divided into 40 mg to 80 mg doses taken one to four times daily, or one to two 160 mg tablets daily.
For patients with cancer or AIDS suffering from appetite loss, muscle wasting or significant weight loss, the usual adult dose is 400 mg to 800 mg as a single daily dose. Patients with AIDS usually use the liquid form of Megestrol, which needs to be shaken well before use.
Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are using the medication without consulting your doctor.
Megestrol should be taken exactly as prescribed. Effectiveness of megestrol acetate should not be judged until two months have passed following the start of therapy. Megestrol can be taken with or without food. The tablets and liquid should be stored at room temperature in a cool, dry place.
If you miss a dose of megestrol, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double up on doses.
Who should NOT take Megestrol?
Megestrol should not be used by:
anyone sensitive or allergic to megestrol acetate or the nonmedicinal ingredients
breast-feeding women
pregnant women during the first four months of pregnancy
What side effects are possible with Megestrol?
The following side effects may go away as your body becomes used to the medicine; check with your doctor if they continue or become bothersome. Your health professional may be able to help you to deal with some of the effects.
More common
dizziness
mild headache
mild blood pressure increase
mood changes
nervousness
pain or swelling in abdomen
swelling of face, ankles, or feet
unusual or rapid weigh gain
Less common
acne
breast pain or tenderness
brown spots on exposed skin
changes in amount of body, facial or scalp hair
hot flashes
loss of sexual interest
sleeping problems
Contact your doctor as soon as possible if the following side effects occur:
More common
changes in vaginal bleeding
dry mouth
frequent urination
increase in blood sugar levels
loss of appetite
unusual thirst
Less common
depression
rash
increased flow of breast milk
Rare
backache
dizziness
filling or rounding out of face
irritability
nausea or vomiting
unusual tiredness or weakness
Get immediate medical attention if any of the following side effects occur:
Rare - signs of blood clotting problems
severe or sudden headache or migraine
severe or sudden loss of or change in speech, coordination, or vision
severe or sudden numbness or pain in chest, arm, or leg
unexplained shortness of breath
Other side effects not listed above may occur in some people. If you notice any other effects, check with your doctor.
Are there any other precautions or warnings for Megestrol?
Pregnancy: Megestrol acetate is not recommended for use in the first four months of pregnancy. Women should use effective birth control when taking megestrol. If you become pregnant while taking megestrol, tell your doctor right away.
Breast-feeding: It is recommended that women not breast-feed while taking megestrol because of the potential for adverse reactions in the nursing infant.
Diabetes: Megestrol can sometimes cause an increase in blood glucose. People with diabetes should monitor their blood sugar levels carefully while taking this drug.
What other drugs could interact with Megestrol?
The following medications may affect how megestrol works or increase the risk of side effects:
testosterone and androgens (for men taking megestrol to treat prostate cancer)
estrogen (form women taking megestrol for breast or endometrial cancer)
If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:
stop taking one of the medications,
change one of the medications to another,
change how you are taking one or both of the medications, or
leave everything as is.
An interaction between two medications does not always mean that you must stop taking one of them. In many cases, interactions are intended or are managed by close monitoring. Speak to your doctor about how any drug interactions are being managed or should be managed.
Medications other than those listed above may interact with Megestrol. Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications that you are taking. Also tell them about any supplements you take. Since caffeine, decongestants, alcohol, the nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.
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