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Parnate is a monoamine oxidase inhibitor (MAOI) used to treat depression. It may also be used to treat other conditions as determined by your doctor.
Why is Parnate prescribed?
Parnate is prescribed for the treatment of major depression--that is, a depressed mood that lasts for at least 2 weeks and interferes with daily functioning. Major depression is marked by at least 4 of the following 8 symptoms: changes in appetite, changes in sleep patterns, agitation or listlessness, loss of interest in usual activities or a decrease in sex drive, fatigue, feelings of guilt or worthlessness, slowed thinking or difficulty concentrating, and thoughts of suicide.
Parnate is a member of the class of drugs known as monoamine oxidase (MAO) inhibitors. It works by increasing concentrations of the brain chemicals epinephrine, norepinephrine, and serotonin.
Where can I order Parnate from? Can I buy Parnate at Canadian Prices?
Yes, if you are from the U.S. then you can buy Parnate at Canadian prices. Currently we will only accept an order for Parnate from U.S. and Canadian residents. Both U.S. and Canadian residents require a prescription to purchase Parnate and when you order Parnate it will be delivered with express shipping.
Most important fact about Parnate
Parnate is a potent drug with the capability of producing serious side effects. It is typically prescribed only if other antidepressants fail, and then only for adults who are under close medical supervision. It is considered especially risky because it can interact with a long list of drugs and foods to produce life-threatening side effects (see "Possible food and drug interactions when taking this medication").
How should you take Parnate?
Your doctor will adjust the dosage of Parnate according to your individual needs and response. The drug usually produces improvement within 48 hours to 3 weeks after starting therapy. --If you miss a dose...Take it as soon as you remember. If it is within 2 hours of your next dose, skip the one you missed and go back to your regular schedule. Never take 2 doses at once. --Storage instructions...
Store Parnate at room temperature.
What Parnate side effects may occur?
Parnate Side effects cannot be anticipated. If any develop or change in intensity, inform your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking Parnate.
Parnate Side effects may include:
Abdominal pain, agitation, altered touch sensation, anxiety, appetite loss, blood disorders, blurred vision, chills, constipation, diarrhea, dizziness, drowsiness, dry mouth, hair loss, headaches, hepatitis, impotence, insomnia, irregular or rapid heartbeat, mania, muscle spasms and jerks, nausea, numbness, overstimulation, restlessness, retarded ejaculation, ringing in ears, reduced urination, skin rashes, tremors, swelling, water retention, weakness
Possible food and drug interactions when taking Parnate
Never take Parnate with the following drugs; the combination can trigger seizures or a dangerous spike in blood pressure:
Other MAO inhibitors such as Nardil
Antidepressant drugs classified as "tricyclics," such as Anafranil, Elavil, and Tofranil
Carbamazepine (Tegretol)
Cyclobenzaprine (Flexeril) When switching from one of these drugs to Parnate, or vice versa, allow an interval of at least 1 week between medications. Also avoid combining Parnate with any of the following:
Antidepressant drugs classified as "selective serotonin reuptake inhibitors," such as Paxil, Prozac, and Zoloft
Amphetamines such as Adderall and Dexedrine
Anesthetics
Antihistamines such as Allegra, Benadryl, and Clarinex
Blood pressure medications such as Accupril, Lotensin, and Prinivil
Bupropion (Wellbutrin)
Buspirone (BuSpar)
Cold and hay fever remedies that constrict blood vessels
Cough remedies containing dextromethorphan
Demerol and other narcotic painkillers such as Percodan, OxyContin, and Vicodin
Disulfiram (Antabuse)
Guanethidine
Methyldopa
Over-the-counter weight reduction aids
Parkinson's disease medications such as Parlodel, Requip, and Sinemet
Reserpine
Sedatives such as Halcion, Nembutal, and Seconal
Tryptophan
Water pills such as HydroDIURIL While taking Parnate, you should also avoid foods that contain a high amount of a substance called tyramine, including:
Anchovies
Avocados
Bananas
Beer (including nonalcoholic beer)
Caviar
Cheese (especially strong and aged varieties)
Chianti wine
Chocolate
Dried fruits (including raisins, prunes, and figs)
Liqueurs
Liver
Meat extracts or meat prepared with tenderizers
Overripe fruit
Pickled herring
Pods of broad beans like fava beans
Raspberries
Sauerkraut
Sherry
Sour cream
Soy sauce
Yeast extracts
Yogurt
Likewise, avoid alcohol and large amounts of caffeine.
Special Parnate information if you are pregnant or breastfeeding
If you are pregnant or plan to become pregnant, inform your doctor immediately. Parnate should be used during pregnancy only if its benefits outweigh potential risks.
Parnate makes its way into breast milk. If the drug is essential to your health, your doctor may advise you to stop nursing until your treatment is finished.
Recommended Parnate dosage
ADULTS The usual dosage is 30 milligrams per day, divided into smaller doses. If ineffective, the dosage may be slowly increased under your doctor's supervision to a maximum of 60 milligrams per day.
Parnate Overdosage
If you suspect an overdose of Parnate, seek medical help immediately.
Symptoms of Parnate overdose may include:
Agitation, confusion, coma, dizziness, drowsiness, high fever, incoherence, rigid muscles, severe headache, twitching, weakness
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